Cajun Chicken Pasta Bake

Featured in: International BBQ Flavors

This vibrant dish combines tender chicken pieces seasoned with aromatic Cajun spices, sautéed with bell peppers and onions to add freshness and depth. A creamy sauce made with a blend of cream and milk melts mozzarella, cheddar, and Parmesan cheeses into a luscious coating for penne pasta. The mixture is baked until golden and bubbly, finishing with a sprinkle of fresh parsley and extra Cajun seasoning to heighten the flavors. Perfect for a satisfying meal that balances spice, creaminess, and rich cheese.

Updated on Sat, 15 Nov 2025 13:06:00 GMT
Cajun chicken pasta bake bubbling hot with melted cheese and tender chicken pieces inside. Save
Cajun chicken pasta bake bubbling hot with melted cheese and tender chicken pieces inside. | bitegrill.com

A vibrant, comforting casserole featuring tender chicken, spicy Cajun seasonings, creamy sauce, and melty cheese, all baked with pasta for a crowd-pleasing meal.

I first made this Cajun Chicken Pasta Bake for a potluck, and it became an instant favorite thanks to its creamy sauce and perfectly spiced chicken. The combination of colorful veggies and cheesy topping always makes it a hit at family gatherings.

Ingredients

  • Chicken breasts: 2 large, cut into bite-sized pieces
  • Red bell pepper: 1, diced
  • Yellow bell pepper: 1, diced
  • Red onion: 1 small, diced
  • Garlic: 2 cloves, minced
  • Pasta: 300 g (10 oz) penne or rigatoni
  • Olive oil: 2 tbsp
  • Butter: 1 tbsp
  • Heavy cream: 200 ml (¾ cup)
  • Milk: 120 ml (½ cup)
  • Mozzarella cheese: 100 g (1 cup), shredded
  • Parmesan cheese: 50 g (½ cup), grated
  • Cheddar cheese: 100 g (1 cup), shredded
  • Cajun seasoning: 1½ tbsp (plus extra for garnish)
  • Smoked paprika: ½ tsp
  • Salt: ½ tsp
  • Black pepper: ¼ tsp
  • Chili flakes: ¼ tsp (optional, for extra heat)
  • Fresh parsley: 2 tbsp, chopped, for garnish

Instructions

Preheat oven:
Preheat your oven to 200°C (400°F).
Cook pasta:
Boil pasta in salted water for 2 minutes less than package instructions. Drain and set aside.
Cook chicken:
In a large skillet, heat olive oil and butter over medium-high heat. Add chicken, 1 tbsp Cajun seasoning, salt, and pepper. Sauté until browned and cooked through, about 6 minutes. Remove and set aside.
Sauté vegetables:
Add onions and bell peppers to skillet. Cook for 4 minutes until softened. Add garlic, smoked paprika, and chili flakes if using. Sauté for 1 minute.
Make sauce:
Reduce heat. Pour in cream and milk, stirring to scrape up any browned bits. Simmer for 2 minutes.
Add cheeses:
Add ¾ of mozzarella, cheddar, and Parmesan. Stir until melted and smooth.
Combine chicken and pasta:
Return chicken to skillet. Add pasta. Toss to coat well and adjust seasoning if needed.
Bake:
Transfer mixture to greased baking dish. Sprinkle remaining cheeses on top. Bake for 18 minutes until cheese is golden and bubbly.
Garnish and serve:
Top with parsley and extra Cajun seasoning before serving.
Golden brown Cajun chicken pasta bake, served steaming, with colorful bell peppers in the creamy sauce. Save
Golden brown Cajun chicken pasta bake, served steaming, with colorful bell peppers in the creamy sauce. | bitegrill.com

The kids love scooping out cheesy servings, and it's the only casserole everyone finishes without complaint! Sharing leftovers is rare in our house when this bake hits the table.

Serving Suggestions

Serve Cajun Chicken Pasta Bake with a crisp green salad or garlic bread for a complete meal. A glass of iced tea or Sauvignon Blanc pairs nicely with the spicy, creamy flavors.

Variation Ideas

Swap the chicken for sausage or add mushrooms and spinach for more veggies. For a lighter version, use half-and-half or reduced fat cheeses in the sauce.

Storage & Reheating

Cool leftovers quickly and store in an airtight container in the fridge for up to 3 days. Reheat portions in the oven covered with foil or in the microwave until piping hot.

Cheesy, baked Cajun chicken pasta, a comforting casserole with parsley garnish, ready to eat. Save
Cheesy, baked Cajun chicken pasta, a comforting casserole with parsley garnish, ready to eat. | bitegrill.com

This Cajun Chicken Pasta Bake is perfect for sharing and always leaves a lasting impression. Enjoy every spicy, creamy bite straight from the oven!

Recipe FAQ

How do I ensure the chicken stays tender?

Sauté the chicken over medium-high heat until browned but not overcooked, about 6-8 minutes, to keep it juicy and tender.

Can I use different types of pasta?

Yes, penne or rigatoni work well as they hold the creamy sauce nicely, but feel free to substitute with similar shapes.

What can I use to add more vegetables?

Add sliced mushrooms or fresh spinach alongside the peppers and onions for extra color and nutrition.

How spicy is the dish and can it be adjusted?

The heat level can be moderated by adjusting the amount of Cajun seasoning and chili flakes to suit your preference.

What is the best way to reheat leftovers?

Cover the dish with foil and warm it gently in the oven until heated through to maintain creaminess and texture.

Cajun Chicken Pasta Bake

Tender chicken with spicy Cajun seasoning, creamy sauce, and melted cheese baked alongside pasta for a hearty meal.

Prep duration
20 min
Cook duration
35 min
Complete duration
55 min
Created by Ethan Walker


Skill Level Medium

Heritage American (Cajun-inspired)

Output 4 Portions

Dietary considerations None specified

Components

Meats

01 2 large chicken breasts, diced into bite-sized pieces

Vegetables

01 1 red bell pepper, diced
02 1 yellow bell pepper, diced
03 1 small red onion, diced
04 2 cloves garlic, minced

Pasta

01 10 ounces penne or rigatoni pasta

Sauces & Dairy

01 2 tablespoons olive oil
02 1 tablespoon butter
03 ¾ cup heavy cream
04 ½ cup milk
05 1 cup shredded mozzarella cheese
06 ½ cup grated Parmesan cheese
07 1 cup shredded cheddar cheese

Spices & Seasonings

01 1½ tablespoons Cajun seasoning, plus extra for garnish
02 ½ teaspoon smoked paprika
03 ½ teaspoon salt
04 ¼ teaspoon black pepper
05 ¼ teaspoon chili flakes (optional)

Garnish

01 2 tablespoons chopped fresh parsley

Method

Phase 01

Preheat oven: Set oven to 400°F.

Phase 02

Cook pasta: Boil pasta in salted water, cooking 2 minutes less than package instructions. Drain and set aside.

Phase 03

Sauté chicken: Heat olive oil and butter in a large skillet over medium-high heat. Add chicken, 1 tablespoon Cajun seasoning, salt, and pepper, cooking 6–8 minutes until browned and cooked through. Remove from skillet.

Phase 04

Cook vegetables: In the same skillet, sauté onions and bell peppers for 4–5 minutes until softened. Add garlic, smoked paprika, and chili flakes if using; cook an additional minute.

Phase 05

Create sauce: Reduce heat to medium. Pour in heavy cream and milk, stirring to deglaze skillet. Simmer for 2–3 minutes.

Phase 06

Melt cheeses: Stir in three-quarters of mozzarella, cheddar, and Parmesan cheese until fully melted and smooth.

Phase 07

Combine chicken and pasta: Return chicken to skillet, add cooked pasta, and toss to coat evenly. Adjust seasoning with additional Cajun seasoning, salt, or pepper as desired.

Phase 08

Assemble casserole: Transfer mixture to a greased baking dish. Sprinkle remaining cheeses on top.

Phase 09

Bake: Bake uncovered for 18–20 minutes until cheese is golden and bubbly.

Phase 10

Garnish and serve: Top with chopped parsley and a pinch of Cajun seasoning before serving.

Tools needed

  • Large skillet or sauté pan
  • Medium saucepan
  • Baking dish (approximately 2 quarts)
  • Wooden spoon
  • Chef's knife and cutting board

Allergy details

Review each ingredient for potential allergens and consult with healthcare providers if you're uncertain about sensitivities.
  • Contains milk (cheese, cream, butter) and wheat (pasta). Potential gluten presence depending on pasta choice. Check spice blend labels for cross-contamination.

Nutritional information (each portion)

These values are provided as estimates only and shouldn't replace professional medical guidance.
  • Energy: 670
  • Fats: 32 g
  • Carbohydrates: 56 g
  • Proteins: 40 g