Cajun Chicken Alfredo

Featured in: Grilled Fruits & Desserts

This Cajun Chicken Alfredo brings together tender Cajun-seasoned chicken breasts with a silky, garlic-infused Alfredo cream sauce over al dente fettuccine. The preparation takes just 40 minutes total, making it perfect for weeknight dinners.

Start by seasoning and searing chicken until golden, then craft your Alfredo sauce with butter, garlic, heavy cream, and freshly grated Parmesan. The magic happens when you toss it all together, allowing the pasta to absorb the creamy coating while the spiced chicken adds a bold contrast.

Serve immediately with fresh parsley and extra Parmesan for a restaurant-quality meal that yields 4 generous portions.

Updated on Sun, 18 Jan 2026 14:43:00 GMT
Creamy Cajun Chicken Alfredo pasta twirled on a fork with tender, spice-rubbed chicken strips and a glossy Parmesan sauce. Save
Creamy Cajun Chicken Alfredo pasta twirled on a fork with tender, spice-rubbed chicken strips and a glossy Parmesan sauce. | bitegrill.com

My neighbor Maria knocked on my door one Thursday evening holding a takeout container and asked if I'd ever tried mixing Cajun spice with Alfredo. I hadn't, but twenty minutes later we were in my kitchen tossing blackened chicken with cream sauce, and I couldn't believe how naturally the heat played with the richness. That impromptu dinner became my most requested dish within a month. Now I keep Cajun seasoning next to my Parmesan because some fusions just make sense.

I made this for my brother's birthday last spring, doubling the batch because his friends always show up hungry. Watching them go quiet after the first forkful, then immediately reach for seconds, told me everything. One friend actually asked if I'd cater her wedding, which I politely declined, but I did write the recipe on a notecard for her. It's become my potluck insurance policy.

Ingredients

  • Boneless, skinless chicken breasts: I pound them to even thickness so they cook uniformly and don't dry out on the edges while the center catches up.
  • Cajun seasoning: Store bought works great, but check the salt level because some blends are heavily salted and you'll need to adjust the sauce.
  • Olive oil: Just enough to get a good sear without making the pan smoke, medium high heat is your friend here.
  • Fettuccine or linguine: The flat noodles grab onto the sauce better than round pasta, and I always cook it one minute under package time since it finishes in the skillet.
  • Unsalted butter: Gives you control over the salt, especially important when Parmesan and Cajun seasoning are already contributing plenty.
  • Garlic: Fresh cloves minced fine, not jarred, the difference is obvious in a sauce this simple.
  • Heavy cream: The backbone of Alfredo, don't substitute milk or it will break and turn grainy instead of silky.
  • Parmesan cheese: Freshly grated from a block melts smoothly, the pre shredded kind has anti caking agents that make the sauce gritty.
  • Black pepper and salt: Season gradually and taste as you go, the pasta water you add later brings salt too.
  • Red pepper flakes: Optional but I always add them for a gentle background heat that builds with each bite.
  • Fresh parsley: Brightens the whole plate and adds a pop of color against the creamy beige.

Instructions

Cook the pasta:
Boil salted water like the sea, drop in your fettuccine, and stir occasionally so nothing sticks. Reserve half a cup of that starchy water before draining, it's liquid gold for adjusting sauce consistency later.
Season the chicken:
Pat the breasts completely dry with paper towels so the seasoning sticks, then rub the Cajun blend all over every surface. Let them sit while the oil heats up.
Sear the chicken:
Lay the breasts in the hot skillet and resist the urge to move them, let them develop a dark crust for five to six minutes. Flip once, cook through, then rest them on a plate before slicing so the juices redistribute.
Build the Alfredo base:
Melt butter in the same skillet, scraping up any browned bits, then add garlic and stir for thirty seconds until it smells toasty. Pour in the cream and whisk gently, bringing it to a bare simmer without boiling or it might split.
Thicken the sauce:
Stir in Parmesan a handful at a time, letting each addition melt before adding more, then season with pepper, salt, and red pepper flakes. Simmer for two to three minutes until it coats the back of a spoon.
Toss and serve:
Add the drained pasta to the skillet and toss with tongs until every strand is glossy. Lay the sliced chicken on top, toss again, and finish with parsley and extra cheese.
Steaming plate of Cajun Chicken Alfredo featuring golden seared chicken and fettuccine tossed in velvety cream sauce, garnished with parsley. Save
Steaming plate of Cajun Chicken Alfredo featuring golden seared chicken and fettuccine tossed in velvety cream sauce, garnished with parsley. | bitegrill.com

My dad, who claims he doesn't like spicy food, scraped his plate clean and asked for the recipe to make for my mom. Watching him scribble notes on a grocery receipt while I talked him through the steps reminded me that good food breaks through stubbornness. He texts me a photo every time he makes it now.

Tweaking the Heat Level

Cajun seasoning varies wildly by brand, some are mild and smoky while others bring serious fire. I start with one tablespoon on the chicken and taste the sauce before adding red pepper flakes, then adjust up or down based on who's eating. For kids or sensitive palates, I cut the Cajun in half and skip the flakes entirely, the dish still has tons of flavor from the garlic and Parmesan.

Making It Your Own

I've tucked sautéed bell peppers and onions into this more times than I can count, especially when I have extra vegetables to use up. Spinach wilts beautifully into the hot sauce, and sun dried tomatoes add a sweet tang that plays well with the spice. Shrimp cooks faster than chicken and works perfectly if you're in a rush, just toss them in the seasoning and sear for two minutes per side.

Storing and Reheating

Leftovers keep for three days in an airtight container in the fridge, and I reheat them gently in a skillet with a splash of cream or milk to loosen the sauce. The microwave works in a pinch but tends to dry out the chicken, so I cover the bowl with a damp paper towel. Freezing isn't ideal because cream sauces separate when thawed, but if you must, undercook the pasta slightly and freeze in portions.

  • Add a squeeze of lemon juice when reheating to wake up the flavors.
  • Toss in fresh arugula or basil right before serving for brightness.
  • Grate extra Parmesan on top because cheese makes everything better.
Fettuccine swimming in rich, garlicky Alfredo sauce topped with sliced Cajun chicken, ideal for a comforting weeknight family dinner. Save
Fettuccine swimming in rich, garlicky Alfredo sauce topped with sliced Cajun chicken, ideal for a comforting weeknight family dinner. | bitegrill.com

This dish proves that breaking a few culinary rules can lead to something better than tradition alone. Keep it on your weeknight rotation and watch it become the meal everyone asks about.

Recipe FAQ

How do I prevent the Alfredo sauce from breaking or becoming too thick?

Keep the heat at medium and whisk constantly when adding cream. Never allow the sauce to boil, as high heat can cause separation. If it thickens too much, gradually add reserved pasta water one tablespoon at a time while stirring gently until you reach the desired consistency.

Can I prepare this dish ahead of time?

It's best served immediately after combining, as the pasta continues absorbing sauce and can become overly thick upon standing. However, you can prepare components separately: cook pasta and chicken in advance, then quickly reheat and combine with freshly made sauce just before serving.

What's the best way to achieve perfectly cooked chicken?

Pat chicken dry before seasoning to ensure good browning. Use medium-high heat and avoid moving the breasts around—let them develop a golden crust for 5-6 minutes per side. Verify doneness with a meat thermometer reading 165°F. Resting for 2-3 minutes after cooking keeps the meat tender and juicy.

Can I substitute the type of pasta?

Absolutely. While fettuccine and linguine work best for coating with creamy sauce, you can use pappardelle, rigatoni, or even penne. Avoid thin pasta like angel hair, which may get weighed down by the heavy sauce. Adjust cooking time based on your pasta choice.

How can I add more vegetables without changing the dish?

Sauté bell peppers, spinach, or mushrooms separately in the same skillet after removing the chicken, then add them back to the sauce. Alternatively, roast vegetables beforehand and fold them in during the final tossing step to maintain their texture and flavor.

What wine pairs best with this dish?

Crisp white wines like Sauvignon Blanc, Pinot Grigio, or Unoaked Chardonnay complement the rich Alfredo and spicy Cajun notes beautifully. The acidity cuts through the cream while the wine's brightness balances the heat from the seasoning.

Cajun Chicken Alfredo

Spicy Cajun-seasoned chicken meets creamy Alfredo sauce in this fusion pasta dish that combines Southern heat with Italian comfort.

Prep duration
15 min
Cook duration
25 min
Complete duration
40 min
Created by Ethan Walker


Skill Level Medium

Heritage American Cajun-Italian Fusion

Output 4 Portions

Dietary considerations None specified

Components

Chicken

01 2 large boneless, skinless chicken breasts
02 1 tablespoon Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 ounces fettuccine or linguine pasta

Alfredo Sauce

01 2 tablespoons unsalted butter
02 3 cloves garlic, minced
03 1 1/2 cups heavy cream
04 1 cup freshly grated Parmesan cheese
05 1/4 teaspoon ground black pepper
06 1/4 teaspoon salt
07 1/4 teaspoon red pepper flakes

Garnish

01 2 tablespoons chopped fresh parsley
02 Extra grated Parmesan cheese for serving

Method

Phase 01

Prepare pasta: Bring a large pot of salted water to a boil. Add fettuccine and cook according to package directions until al dente. Reserve 1/2 cup pasta water, drain remainder, and set aside.

Phase 02

Season chicken: Pat chicken breasts dry with paper towels and rub evenly on both sides with Cajun seasoning.

Phase 03

Cook chicken: Heat olive oil in a large skillet over medium-high heat. Add chicken breasts and cook 5-6 minutes per side until golden brown and internal temperature reaches 165°F. Remove from skillet, rest 2-3 minutes, then slice into strips.

Phase 04

Build Alfredo sauce: In the same skillet over medium heat, melt butter. Add minced garlic and sauté 30 seconds until fragrant. Pour in heavy cream while whisking constantly and bring to a gentle simmer without boiling.

Phase 05

Finish sauce: Stir in Parmesan cheese, black pepper, salt, and red pepper flakes. Simmer 2-3 minutes until sauce thickens. If too thick, add reserved pasta water one tablespoon at a time.

Phase 06

Combine components: Add cooked pasta to the skillet and toss thoroughly to coat with Alfredo sauce. Add sliced Cajun chicken and toss again until evenly distributed.

Phase 07

Plate and serve: Divide between serving plates immediately. Garnish with chopped fresh parsley and additional grated Parmesan cheese.

Tools needed

  • Large pot
  • Large skillet
  • Tongs
  • Chef's knife
  • Cutting board
  • Measuring cups and spoons
  • Whisk

Allergy details

Review each ingredient for potential allergens and consult with healthcare providers if you're uncertain about sensitivities.
  • Contains milk from heavy cream, butter, and Parmesan cheese
  • Contains wheat from pasta
  • May contain eggs if using fresh pasta
  • Verify Cajun seasoning ingredient label for gluten or other potential allergens

Nutritional information (each portion)

These values are provided as estimates only and shouldn't replace professional medical guidance.
  • Energy: 670
  • Fats: 34 g
  • Carbohydrates: 54 g
  • Proteins: 40 g